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人乳头瘤病毒(HPV)能诱导皮肤粘膜产生肿瘤,宫颈癌已证实有HPV-DNA,HPV6型、11型在宫颈异常发育上皮中常见,而16、18、31和33型常见于宫颈内上皮肿瘤,HPV-16DNA频繁见于浸润性宫颈癌中。本文研究的43例浸润性宫颈癌患者均行子官切除术及骨盆淋巴结和主动脉旁淋巴结切除。标本切片做病理分析,每例肿瘤都用DNA分子杂交技术证实是否存在HPV-16DNA。结果表明,43例肿瘤中,22例为HPV阳性,21例阴性,而HPV-16阳性肿瘤患者与阴性患者在年龄、临床分期、组织分
Human papillomavirus (HPV) can induce skin mucous membrane tumor, cervical cancer has been confirmed with HPV-DNA, HPV type 6, type 11 in the abnormal development of cervical epithelial common, and 16,18,31 and 33 are common in the endocervical epithelium Tumors, HPV-16 DNA is frequently found in invasive cervical cancer. In this paper, 43 cases of invasive cervical cancer patients underwent resection and pelvic lymph nodes and para-aortic lymph node resection. Specimens were taken for histopathological analysis. In each case, DNA hybridization was used to confirm the presence or absence of HPV-16 DNA. The results showed that of the 43 tumors, 22 were HPV positive and 21 were negative, while HPV-16 positive and negative patients in the age, clinical stage, tissue