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为探讨铅对儿童神经系统的影响，本研究在国内首次用齿铅作为儿童体内铅负荷指标，以韦克斯勒学龄前儿童智力量表（ＷＰＰＳＩ－Ｒ）修订版测得的智商（ＩＱ）作为智力发育效应指标，研究了学龄前儿童齿铅与智商的关系，并对可能影响智商的其它混杂因素进行问卷调查。结果表明：简单相关分析时，发现齿铅（２．００～１７．２１μｇ／ｋｇ）与分测验中的迷津、算术、木块图案、总ＩＱ和语言ＩＱ存在显著负相关（Ｐ＜０．０５）；而与操作ＩＱ、常识等其他项的相关则无显著性（Ｐ＞０．０５）。多因素分析时，发现引入母亲文化程度、父亲文化程度、父亲职业、母亲生育年龄和父母关心程度等混杂因素后，铅的这种负作用即减弱至无显著性（Ｐ＞０．０５）
To explore the effect of lead on children’s nervous system, this study firstly used lead to lead in children in China as the indicator of lead load in children and IQ (IQ) in the Wechsler Preschool Children’s Intelligence Scale (WPPSI-R) As an indicator of mental developmental effects, the relationship between dental lead and IQ in preschool children was studied, and other confounding factors that may affect IQ were surveyed. The results showed that tooth lead (2.00 ~ 17.21μg / kg) was significantly and negatively correlated with maze, math, wood block pattern, total IQ and language IQ in the simple test (P <0.05 ), While there was no significant correlation with IQ, common sense and other items (P> 0.05). In the multivariate analysis, it was found that this negative effect of lead was weakened to an insignificant level (P> 0.05) after introducing confounding factors such as mother’s education level, father’s education level, father’s occupation, mother’s childbearing age and parents’