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目的：研究原发性皮肤恶性淋巴瘤（ＰＣＭＬ）的类型及临床病理特点。方法：对４２例ＰＣＭＬ作了形态学观察、免疫表型标记和组织学分型。结果：原发性皮肤Ｔ细胞性淋巴瘤（ＰＣＴＣＬ）占６９．０％，其中蕈样霉菌病占７．２％（ＭＦ）、血管中心性淋巴瘤占９．５％、皮下脂膜炎样Ｔ细胞淋巴瘤占１９．０％，原发性皮肤Ｂ细胞性淋巴瘤（ＰＣＢＣＬ）占３１．０％；ＰＣＭＬ男女之比为２∶１，中位年龄３７岁，ＰＣＴＣＬ的发病年龄小于ＰＣＢＣＬ（Ｐ＜０．０１），低度恶性组的发病年龄大于高恶组（Ｐ＜０．０１）；除ＭＦ外，临床表现主要为无症状的皮肤结节或包块，部分ＰＣＴＣＬ皮损形成溃疡，ＰＣＢＣＬ则无；组织学上ＰＣＴＣＬ浸润较浅，可有亲表皮现象，ＰＣＢＣＬ浸润较深，无此现象。结论：ＰＣＭＬ各型有独特的临床病理表现，各类型的分布变化较大。
Objective: To study the type and clinicopathological features of primary cutaneous lymphoma (PCML). Methods: Morphological observations, immunophenotypic markers and histological types were performed on 42 cases of PCML. RESULTS: Primary cutaneous T-cell lymphoma (PCTCL) accounted for 69.0%, with mycosis fungolis accounted for 7.2% (MF), angiocentric lymphoma accounted for 9.5%, subcutaneous panniculitis-like T-cell lymphoma accounted for 19.0%, primary skin B-cell lymphoma (PCBCL) accounted for 31.0%; PCML ratio for men and women was 2:1, the median age was 37 years, and the age of onset of PCTCL was less than PCBCL ( P<0.01). The age of onset was lower in the low-grade group than in the high-grade group (P<0.01). The clinical manifestations were mainly asymptomatic nodules or masses except MF. Some PCTCL lesions formed ulcers. PCBCL is not; Histological PCTCL infiltration is shallow, there may be pro-epidermal phenomenon, PCBCL infiltration is deep, no such phenomenon. Conclusion: There are unique clinicopathological features of various types of PCML, and the distribution of each type varies greatly.