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Background Rapid progression of non-culprit coronary artery lesion happens in some patients after percutaneous coronary intervention(PCI).However,the incidence and prognostic factors for progression of coronary lesion are not clarified.Methods The patients who underwent two coronary angiography (CAG) from January 2015 to January 2017 in our hospital were selected as objects of this retrospective study.According to the resuits of the second CAG,they were divided into control group (No restenosis in the stent,no change or improvement of out-stent lesions,n=42) and lesion progression group (Aggravation of out-stent lesions,n =29).The clinical data of patients between the two groups were analyzed by statistics.Results The change of Lipoprotein (a) (Lp(a))and uric acid (UA) in lesion progression group were significantly different from control group (P=0.004 and P=0.037).Regression analysis showed that,the change of UA was an independent predictive factor of coronary artery lesion progression in a short time (6 ～ 12 months)after PCI (odds ratio [OR]:1.007;95％ confidence interval [CI]:(1.000,1.013);P=0.042).Conclusion UA is an independent predictive factor of non-culprit coronary artery lesion after stent implanting.