发展多价痢疾疫苗的一种策略就是构建一系列定位于质粒的 vir G缺失突变株。研究人员曾构建 2 a型福氏志贺菌Δ vir G株 ,并在志愿者中进行安全性与免疫原性评估。作者报告了口服 Δvir G宋内志贺菌候选株WRSS1在健康成人中的 期临床试验结果。　　 WRSS1疫苗由美国 Walter Re One strategy for developing multivalent diarrhea vaccines is to construct a series of virG-deficient mutants that are localized to the plasmid. Researchers have constructed 2 a-strain of shigella flexneri viru strain and evaluated safety and immunogenicity in volunteers. The authors report the results of a phase clinical trial of Ovir G Shigella sonnei candidate strain WRSS1 orally in healthy adults. WRSS1 vaccine by the United States Walter Re