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自1842年意大利医师Rigoni-Stern报告未婚女性宫颈癌发病率明显低且尼姑类处女几乎未见有宫颈癌以来,相继出现大量验证性报告,这是流行病学提出宫颈癌与性交之间密切相关的重要发现,而后形成了宫颈癌与性传播疾病(STD)中也有病毒参与设想的基础。对由性交引起且能传播的致癌物质引起了重视。并进行了各种流行病学调查,结果于二十世纪七十年代首先成为重点的是STD病原体之一的单纯疱疹病毒Ⅱ型(HSV-2)。HSV-2经性交传播,使支配最初感染部位的神经节引起潜伏性感染并反复复发,当时相继报告了宫颈癌患者血清中抗HSV-2抗体阳性率较健康人明显增高。另一方面,实验证明该病毒可使培养
Since 1842 the Italian physician Rigoni-Stern reported a significantly lower incidence of cervical cancer in unmarried women and few nun-class virgins have seen cervical cancer since there have been a large number of confirmatory reports, which is epidemiological cervical cancer and sexual intercourse was closely related And then formed the basis for the idea of viral involvement in cervical cancer and sexually transmitted diseases (STDs). Caused by sexual intercourse and can cause cancer caused by the spread of attention. And conducted various epidemiological investigations. As a result, herpes simplex virus type 2 (HSV-2), one of the STD pathogens, first became the focus of the 1970s. HSV-2 transmission by sexual intercourse, the control of the initial infection sites of the ganglion caused by latent infection and recurrent, were reported in patients with cervical cancer serum anti-HSV-2 positive rate was significantly higher than healthy people. On the other hand, experiments show that the virus can be cultured