成人运动神经元疾病(motor neuron disease,MND)和肌萎缩性侧索硬化症(amyotrophic lateralsclerosis,ALS)的发病机理仍不清楚,病毒、金属、毒素、免疫机能障碍和内分泌异常等因素都与 MND有关,但可能仅与 MND 的几种临床类型有关而不包括所有病人。病人和方法 1983～1987年,作者在约30万人口中发现了11例 ALS 新病例,其中5例是纺织厂工人,5例均为男性,年龄50～65岁,2例来自同一工厂,另 The pathogenesis of motor neuron disease (MND) and amyotrophic lateral sclerosis (ALS) in adults is still unclear. Factors such as viruses, metals, toxins, immune dysfunction and endocrine abnormalities are associated with MND , But may only be related to several clinical types of MND and not all patients. Patients and Methods From 1983 to 1987, the authors identified 11 new cases of ALS among an estimated 300,000 people, 5 of whom were textile mill workers, 5 of whom were men, aged 50-65 years, 2 from the same factory and another