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目的：探讨新生儿感染时外周血CD64及CD3、CD4、CD8的表达，为新生儿细菌感染的早期诊断和细菌感染时细胞免疫功能的评价提供循证支持。方法应用流式细胞仪定量检测120例感染和非感染新生儿外周血CD64分子及CD3、CD4、CD8的表达变化，并将败血症组患儿的CD64与C反应蛋白(CRP)、白细胞计数及血培养进行比较。结果败血症组CD64为（6.7±2.8），高于局部感染组（4.1±1.4）与非感染组(2.9±0.5)，差异有统计学意义（P0.05）。结论 CD64可作为新生儿细菌感染的早期诊断指标，严重细菌感染患儿存在细胞免疫功能紊乱，T淋巴细胞亚群检测对新生儿细胞免疫功能的评价有重要意义。“,”Objective To investigate neonatal infection in peripheral blood CD64 and CD3, CD4, CD8 expression for the early diagnosis of neonatal bacterial infection and bacterial infection celular immune function evaluation of evidence-based support. Methods 120 cases of flow cytometry detection of neonatal infection and non-infected peripheral blood CD64 molecule and CD3, CD4, CD8 expression changes, and sepsis in children with CD64 and C-reactive protein (CRP), white blood cellcount and blood training for comparison. Result CD64 as a result of sepsis group (6.7±2.8), higher than the local infection group (4.1±1.4) and non-infected group (2.9±0.5), the difference was statisticaly significant (P0.05). Conclusion CD64 can be used as an early diagnosis of neonatal bacterial infection indicators of serious bacterial infections in children with immune dysfunction, T lymphocyte subsets in the newborn immune function evaluation is important.