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目的观察丁苯酞治疗急性穿支动脉疾病型脑梗死的临床疗效和安全性。方法 98例患者随机分为治疗组和对照组,每组49例,对照组常规治疗,治疗组在常规治疗基础上加用丁苯酞。治疗第7天、14天应用NIHSS和日常生活能力评分量表对两组进行评估。结果治疗组总有效率为61.2%,对照组为42.9%,差异有显著性;治疗组NIHSS评分在治疗后第7天和第14天分别为6.53±2.82和4.25±2.65,明显优于对照组的8.84±2.94和6.86±2.76;治疗组日常生活能力量表评分在治疗后第7天和第14天分别为73.32±20.46和86.78±19.34,明显优于对照组的61.66±20.29和68.43±18.76;两组不良反应无显著差别。结论丁苯酞治疗急性穿支动脉疾病型脑梗死安全有效。
Objective To observe the clinical efficacy and safety of butylphthalide in the treatment of acute perforation of cerebral infarction. Methods A total of 98 patients were randomly divided into treatment group and control group, with 49 cases in each group. The control group received routine treatment and the treatment group received butylphthalide on the basis of routine treatment. On the 7th and 14th day after treatment, NIHSS and daily living ability score scale were used to evaluate the two groups. Results The total effective rate was 61.2% in the treatment group and 42.9% in the control group, with a significant difference. The NIHSS score of the treatment group was 6.53 ± 2.82 and 4.25 ± 2.65 on the 7th and 14th days after treatment, which was significantly better than the control group Of 8.84 ± 2.94 and 6.86 ± 2.76, respectively. The score of daily living scale in the treatment group was 73.32 ± 20.46 and 86.78 ± 19.34 on the 7th and 14th day after treatment, which was significantly better than that of the control group (61.66 ± 20.29 and 68.43 ± 18.76) There was no significant difference between the two groups. Conclusion Butylphthalide is safe and effective for acute cerebral infarction with perforating artery disease.