抗分泌药物因其副反应一般不用于治疗急性腹泻,但racccadotril是例外,它是脑啡肽酶的特异性抑制剂,治疗成人腹泻的效果和安全性均高。此研究旨在明确racecadotril对儿童严重急性腹泻的疗效和耐受性。 方法:此研究为随机、双盲、有安慰剂对照 Anti-secrete drugs are generally not used for the treatment of acute diarrhea due to their side effects, except for racccadotril, which is a specific inhibitor of neprilysin and is effective and safe in treating adult diarrhea. The aim of this study was to determine the efficacy and tolerability of racecadotril in children with severe acute diarrhea. METHODS: This study was randomized, double-blind, placebo-controlled