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自链霉素、对氨柳酸、异烟肼相继问世后,结核病治疗进入化疗时代,治愈率显著提高到90％以上,而复发率、患病率与病死率亦大幅度下降,这是结核病治疗史上划时代的改变。可是目前复治、难治的肺结核并不少见,这并非化疗效果不好,主要是没有坚持规律化疗或用药不当,其根本原因是对化疗原则的理解与掌握不够。 1978年全国结核病防治工作会议将结核病化疗五项原则修订为“早期、联用、适量、规律、全程”。 1 早期
Since streptomycin, salicylic acid and isoniazid come into being one after another, the treatment of tuberculosis has entered the era of chemotherapy and the cure rate has been significantly raised to more than 90%, while the recurrence rate, prevalence and mortality rate have also dropped drastically. This is due to tuberculosis Epoch-making changes in the history of treatment. However, the current retreatment, refractory tuberculosis is not uncommon, this is not a chemotherapy effect is not good, mainly did not adhere to regular chemotherapy or improper medication, the fundamental reason is the understanding and mastery of the principle of chemotherapy is not enough. In 1978, the national tuberculosis prevention and treatment work conference revised the five principles of tuberculosis chemotherapy as “early, combined, appropriate, regular and full-scale.” 1 early