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目的：观察通心络胶囊联合胺碘酮治疗冠心病(CHD)并发频发室性早博(PVC)的临床疗效。方法将我院44例CHD并发频发性PVC患者随机分为两组各22例，对照组口服盐酸胺碘酮片，1片/次，3次/d，逐步减少用药次数至1次/d；观察组在此基础上加用通心络胶囊，3粒/次，3次/d，两组连续用药6个疗程。治疗期间密切观察两组患者早搏次数、血压、心率、常规心电图、24h Holter心电图、不良反应及临床症状改善情况等，定期检测血尿常规、甲状腺功能及肝肾功能等。结果治疗6个疗程后，观察组和对照组临床症状改善总有效率分别为90.9%和81.8%，24h Holter心电图改善总有效率分别为95.5%和86.4%，不良反应发生率分别为9.1%和18.2%，组间差异均有统计学意义(P <0.05)。结论通心络胶囊联合胺碘酮治疗CHD并发频发性PVC疗效肯定，安全性高，值得临床应用。“,”Objective To observe the effects of Tongxinluo capsule combined with amiodarone in the treatment of coronary heart disease(CHD) complicated with frequent ventricular premature beat(PVC) clinical curative effect. Methods According to the random number table method in Department of Cardiology in our hospital treated 44 cases of CHD complicated with recurrent PVC were divided into control group and observation group, 22 cases in each. The control group were given oral amiodarone hydrochloride tablets, 1 tablets each time, 3 times/day, gradually reduce the number of drugs to 1 times/day; the patients in observation group were administrated Tongxinluo capsule, 3 capsules each time, 3 times/day, two groups after 6 courses of 180d. Close observation during treatment of patients in the two groups, blood pressure, heart rate, heart rate, electrocardiogram, 24h Holter electrocardiogram, adverse reactions and the improvement of clinical symptoms, blood and urine routine, periodic detection of thyroid function and the function of liver and kidney etc. Results After 6 course of treatment, clinical symptoms improved in the total effective rate was 90.9% and 81.8% in the observation group and the control, improve the 24h Holter ECG total effective rate were 95.5% and 86.4%, the incidence of adverse reactions were 9.1% and 18.2%, differences were statistically significance(P <0.05). Conclusion Tongxinluo capsule combined with amiodarone in treatment of CHD complicated with frequent positive PVC curative effect, high safety, and is worth in clinical application.