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目的探讨外周血单核细胞Toll样受体2、4(TLR2、TLR4)的表达与糖尿病慢性肾脏疾病(CKD)发生的关系。方法测定60例糖尿病患者(T2DM组)及68例早期CKD患者(CKD组)外周血单核细胞TLR2、TLR4受体的表达。检测相关临床资料,并进行单因素方差分析和Logistic逐步回归分析。结果 CKD患者外周血单核细胞TLR2及TLR4表达增加,TLR2、TLR4、HbA1c,TC,LDL-C是CKD发生的独立危险因素。结论外周血单核细胞TLR2,TLR4受体表达与CKD的发生有关。
Objective To investigate the relationship between the expression of TLR2 and TLR4 in peripheral blood mononuclear cells and the occurrence of chronic kidney disease (CKD) in diabetic patients. Methods The expressions of TLR2 and TLR4 in peripheral blood mononuclear cells of 60 diabetic patients (T2DM group) and 68 early CKD patients (CKD group) were determined. The related clinical data were detected and analyzed by one-way ANOVA and Logistic stepwise regression analysis. Results The expression of TLR2 and TLR4 in peripheral blood mononuclear cells increased in CKD patients. TLR2, TLR4, HbA1c, TC and LDL-C were independent risk factors for CKD. Conclusion The expression of TLR2 and TLR4 in peripheral blood mononuclear cells is related to the occurrence of CKD.