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骨肉瘤是最常见的骨源性恶性肿瘤,临床极易发生肺转移,其中15%~20%的病例通常在确诊后不久就发生影像学可查见的肺转移灶,约有80%的病例存在影像学检查无法查见的微转移灶[1],因而几乎所有的骨肉瘤患者在行手术切除前后都会使用化疗。本文通过测量25例骨肉瘤患者细胞核面积和圆度系数,根据肿瘤组织对术前化疗反应的好坏将患者分为大核组和小核组,分析细胞核大小和形
Osteosarcoma is the most common malignant tumor of the bone and is clinically prone to lung metastases. Of these, 15% to 20% of cases are usually diagnosed with radiologically detectable lung metastases shortly after diagnosis, and about 80% of cases There are micrometastases that are not detectable by imaging studies [1], so that almost all patients with osteosarcoma use chemotherapy before and after surgical resection. By measuring the nucleus area and roundness coefficient of 25 patients with osteosarcoma, the patients were divided into large nucleus group and small nucleus group according to the tumor response to preoperative chemotherapy.