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为探讨补肾密骨液预防绝经后骨质疏松症的作用及机理，选用４０只８月龄雌性Ｗｉｓｔａｒ大鼠随机分为：假手术组、卵巢切除组、卵巢切除后用雌二醇组、卵巢切除后用补肾中药组和卵巢切除后用盐水组。用药均在卵巢切除后第二天进行。１０周后，取大鼠胫骨近端制成不脱钙骨切片行骨组织形态计量学测定。结果显示，卵巢切除后大鼠小梁骨体积、矿化小梁骨体积降低，表明绝经后骨质疏松症动物模型成立。补肾密骨液组其小梁骨体积与矿化小梁骨体积明显高于盐水组，而其反映骨形成，矿化和骨吸收的指标均下降，表明补肾密骨液可抑制升高的骨转换，且抑制吸收强于抑制形成，进而使骨转换降低而防止骨量丢失。
To explore the effect and mechanism of Bushen Miguye on prevention of postmenopausal osteoporosis, 40 8-month-old female Wistar rats were randomly divided into sham operation group, oophorectomy group, estradiol group after oophorectomy, ovary After the resection, the kidney group and the ovariectomized saline group were used. Medications were performed on the second day after ovariectomy. After 10 weeks, the histological measurements were made by taking the non-decalcified bone sections from the proximal humerus of rats. The results showed that the volume of trabecular bone and the volume of mineralized trabecular bone in ovariectomized rats decreased, indicating that the animal model of postmenopausal osteoporosis was established. The volume of trabecular bone and mineralized trabecular bone in the Bushen Miguye group was significantly higher than that in the saline group, and the indicators of bone formation, mineralization, and bone resorption were all decreased, suggesting that Bushen Miguye can inhibit elevated bone Transformation, and inhibition of absorption is stronger than inhibition of formation, thereby reducing bone turnover and preventing loss of bone mass.