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妊高征的预防是临床的一个重要目标。最近,对于血管内皮前列腺素(PG)的生成与血小板间相互作用的发现不但阐明了妊高征的发病机理而且提供了一种预防此病的方法。据有关报导提出,应用小剂量阿司匹林可有效地预防妊高征。不少资料认为:妊高征的发生原因是由于前列腺环素(PGI_2)与血栓素 A_2(TX A_2)之间平衡失调。这两种 PG 对血管平滑肌及血小板有相反的作用。前者使血管扩张,后者使血管收缩并促进血小板向血管壁聚集及粘附。已证明,在妊高征中有 PGI_2的不足及 TXA_2的增加。适当的 PGI_2与 TX A_2比率在妊娠中对调节循环及维持正常子宫胎盘功能是必要的。直接注射 PGI_2或选择性抑制 TX A_2合成酶均能阻止血压
PIH prevention is an important clinical goal. Recently, the discovery of the interaction between platelet-derived prostaglandin (PG) production and vascular endothelial prostaglandin (PG) not only elucidated the pathogenesis of PIH but also provided a method to prevent this disease. According to reports made, the application of low-dose aspirin can effectively prevent pregnancy-induced hypertension. A lot of information that: PIH due to prostacyclin (PGI_2) and thromboxane A_2 (TX A_2) imbalance between. Both PGs have the opposite effect on vascular smooth muscle and platelets. The former causes blood vessels to dilate, the latter to vasoconstrict and promote platelet aggregation and adhesion to the vessel wall. It has been demonstrated that there is a deficiency of PGI_2 and an increase of TXA_2 in PIH. The appropriate ratio of PGI_2 to TX A_2 is necessary during pregnancy to regulate the circulation and maintain normal uterine placental function. Direct injection of PGI 2 or selective inhibition of TX A 2 synthase can block blood pressure