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辅酶Q_(10)是细胞内呼吸链中氧化还原传递因子,其存在于线粒体的电子传递系统内,在哺乳动物的心、肝、肾上腺及肾脏中含量很高。大白鼠实验表明,外源性~(11)C-CoQ_1。可在较长时间内与心肌细胞线粒体内膜结合。本文应用正电子发射断层显像(PECT)研究~(11)C-CoQ_(10)在缺血性心脏中的分布。同时,对比用HCO-60及脂质体乳化~(11)C-CoQ_(10)的生物学分布特点。方法:~(11)C-CoQ_(10)的制备:3-去甲基-CoQ_(10)与~(11)CHI 反应合成比活度为4～5Ci/mmol 的~(11)C-CoQ_(10),然后分别用两种方法制备~(11)C-CoQ_(10)(HCO-60在生理
Coenzyme Q_ (10) is a redox transporter in the respiratory chain of cells, which is present in the mitochondrial electron transport system and is found in mammalian hearts, liver, adrenal and kidney. Rats experiments show that exogenous ~ (11) C-CoQ_1. In a longer period of cardiomyocyte mitochondrial inner membrane binding. In this paper, positron emission tomography (PECT) was used to study the distribution of ~ (11) C-CoQ_ (10) in ischemic heart. At the same time, we compared the biological distribution of ~ (11) C-CoQ_ (10) with HCO-60 and liposomes. Methods: The preparation of (11) C-CoQ_ (10): The reaction of 3-demethyl-CoQ_ (10) with ~ (10), and then prepared by two methods respectively ~ (11) C-CoQ_ (10) (HCO-60 in physiology