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目的通过对骨性安氏Ⅲ类错亲子之间的不同颅颌面结构的遗传度研究,探讨遗传因素在骨性安氏Ⅲ类错发病中的作用。方法对65例骨性安氏Ⅲ类错患者及其父母拍摄头颅侧位片,选取29个测量标志点,26个测量项目,分别用均父母-子代回归系数法和单亲-子代回归系数法估算不同测量项目的遗传度。结果均父母-子代回归系数法显示,亲子之间颅骨、上下颌骨有很高的遗传度,达到70%~90%,角度的遗传度高于线距的遗传度,代表牙齿和软组织的大部分测量项目的遗传度都在30%~40%左右。单亲-子代回归系数法显示,硬组织和软组织中母子的遗传度大于父子的遗传度,性别在亲子间的遗传有一定的影响。结论亲代的颅颌面结构特征在一定程度上可以预测子代颌骨的生长发育。
Objective To investigate the effect of genetic factors in the pathogenesis of skeletal Class Ⅱ malocclusion by studying the heritability of different cranial and maxillofacial structures between skeletal class Ⅲ malocclusion. Methods Sixty-six patients with skeletal Class Ⅱ malocclusion and their parents were enrolled in this study. Twenty-nine measurement markers and 26 measurement items were selected. The regression coefficients of parents-offspring and single parent-offspring regression coefficients Method to estimate the heritability of different measurement items. The results of both parents - offspring regression coefficient method showed that the parent-child skull, upper and lower jaws have a high degree of heritability, reaching 70% to 90%, the degree of heredity is higher than the line-distance heritability, representing the teeth and soft tissue The heritability of most of the measurement items is about 30% ~ 40%. The single parent-offspring regression coefficient method showed that the heritability of mother and child in hard tissue and soft tissue was greater than the heritability of father and son, and the gender had a certain influence on the inheritance between parents and children. Conclusion The characteristics of cranial and maxillofacial structure of the parents can predict the growth and development of the mandible in a certain extent.