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目前治疗日本血吸虫病的主要药物仍是酒石酸锑钾,但静脉注射安全度小,口服虽有一定疗效,而肠胃道副反应严重。为了提高疗效、降低毒性和口服的副反应,我们筛选了一系列酒石酸锑钾衍生物与复合物,其中疗效较理想的为酒石酸锑钾隣苯三酚(C_(10)H_(10)O_(10)KSb)(以下简称S.J.209)。本文报导其毒性和对小白鼠日本血吸虫病的实验防治结果。S.J.209与硬脂酸熔融后加入虫胶(或玉蜀黍阮)等辅料所制成的口服缓解片,当剂量达20—30毫克/公斤时对犬不引起肠胃道副反应,粪便中亦找不到完整片子。考虑缓解片在体内是否吸收良好,因而进行了疗效试验。
The current treatment of schistosomiasis japonicus is still the main drug antimony potassium tartrate, but the safety of intravenous injection of small, although a certain effect of oral administration, and gastrointestinal side effects. In order to improve curative effect, reduce toxicity and oral side effects, we screened a series of antimony potassium tartrate derivatives and complexes, among which the anti-potassium tartaric acid pyrogallol (C_ (10) H_ (10) O_ 10) KSb) (hereinafter referred to as SJ209). This article reports its toxicity and experimental control of Schistosoma japonicum in mice. SJ209 and stearic acid after the addition of shellac (or corn Nguyen) and other excipients made of oral remission tablets, when the dose of 20-30 mg / kg on dogs does not cause gastrointestinal side effects, nor in the stool to find To the full movie. Considered to ease the tablets in the body is well absorbed, and thus a curative effect test.