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胰蛋白酶原及蛋白酶激活受体-2(PAR-2)在胃肠癌细胞中有异常表达。胰蛋白酶能直接降解细胞外基质,激活其他蛋白水解酶,加强对细胞外基质、基底膜的降解,促进恶性肿瘤的侵袭转移。还能作为一种信号分子,通过激活蛋白酶激活受体-2(PAR-2),增加其他蛋白水解酶的产量,并促进癌细胞的增殖,其表达与预后密切相关。胰蛋白酶原及PAR-2抑制剂能有效阻断其促进肿瘤增生。研究结果为评价胃肠癌的生物学行为、判断预后提供新的指标,为肿瘤药物治疗提供了新的靶点,为相应的抗肿瘤药物的开发提供了一定的实验依据及理论基础。
Trypsinogen and proteinase-activated receptor-2 (PAR-2) are abnormally expressed in gastrointestinal cancer cells. Trypsin can directly degrade the extracellular matrix, activate other proteolytic enzymes, enhance the degradation of extracellular matrix and basement membrane, and promote the invasion and metastasis of malignant tumors. But also acts as a signaling molecule that activates receptor-2 (PAR-2) to increase the yield of other proteolytic enzymes and promote the proliferation of cancer cells, the expression of which is closely related to the prognosis. Trypsinogen and PAR-2 inhibitors can effectively block its promotion of tumor proliferation. The results provide a new target for evaluating the biological behavior of gastrointestinal cancer and prognosis, provide a new target for the treatment of cancer drugs, and provide some experimental basis and theoretical basis for the development of the corresponding anti-cancer drugs.