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目的探讨对氨基水杨酸钠(PAS-Na)对锰致大鼠肝微粒体、线粒体抗氧化酶及病理学改变的影响。方法50只雄性SD大鼠按体重随机分为对照组和染锰组。染锰组腹腔注射(ip)Mn Cl2·4H2O 15 mg/kg,对照组ip等容量生理盐水,1次/d,每周5 d,连续6周。随后,将染锰组按体重随机分为染锰、低、中、高剂量PAS-Na治疗(L、M、H-PAS)组。L、M、H-PAS组大鼠分别背部皮下注射(sc)PAS-Na 100、200和300 mg/kg,对照组、染锰组背部sc等容量生理盐水,1次/d,每周4 d,连续4周。测定肝线粒体、微粒体超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性,并观察肝组织病理学改变。结果与对照组比较,染锰组肝线粒体SOD和GSH-Px、微粒体SOD活性降低,但差异无统计学意义(P>0.05)。染锰组肝脏系数增大,肝脏汇管区出现炎性淋巴细胞及中性粒细胞浸润,肝小叶内出现点状坏死,甚至部分灶性坏死,部分肝细胞出现脂肪变性;与染锰组比较,M-PAS组点状坏死灶明显减少,L、H-PAS组点状坏死灶也有所减少。结论染锰可使大鼠肝脏汇管区出现炎性淋巴细胞及中性粒细胞浸润,肝小叶点状坏死,甚至部分灶性坏死,肝细胞脂肪变性,PAS-Na治疗可使其病理形态学改变明显好转。
Objective To investigate the effects of sodium salicylate (PAS-Na) on liver microsomes, mitochondrial antioxidant enzymes and pathological changes in rats induced by manganese. Methods Fifty male SD rats were randomly divided into control group and manganese-dosed group according to their body weight. The rats in the Mn-exposed group were intraperitoneally injected with MnCl 2 · 4H 2 O 15 mg / kg and the control group ip with the same volume of normal saline once a day for 5 days for 6 weeks. Subsequently, the manganese-exposed groups were randomly divided into groups receiving manganese, low, medium and high doses of PAS-Na (L, M, H-PAS). Rats in L, M and H-PAS groups were injected subcutaneously (sc) PAS-Na 100, 200 and 300 mg / kg into the dorsal scalds respectively. d, for 4 weeks. The activities of hepatic mitochondria, microsomal SOD and GSH-Px were measured, and pathological changes of liver were observed. Results Compared with the control group, the activities of SOD and GSH-Px in liver mitochondria and the activity of SOD in microsomes in the Mn-dosed group decreased, but the difference was not statistically significant (P> 0.05). In the manganese-exposed group, hepatic coefficient increased, inflammatory lymphocytes and neutrophil infiltration occurred in the hepatic portal area, spot-like necrosis occurred in the hepatic lobule, and even partial focal necrosis and some hepatocytes showed steatosis. Compared with the manganese-treated group, M-PAS group of punctate necrosis significantly reduced, L, H-PAS group of punctate necrosis also decreased. Conclusion Dyeing of manganese can induce infiltration of inflammatory lymphocytes and neutrophils in rat hepatic portal area, focal necrosis of hepatic lobules, and even partial focal necrosis and fatty degeneration of hepatocytes. PAS-Na treatment can change the pathological changes Obvious improvement.