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目的 探讨胎儿鼻软骨、鼻肌及鼻皮肤发育规律 ,为鼻的胚胎发育及年龄解剖学提供资料。 方法 对 39例 3～ 10月龄的胎儿游离软骨性外鼻标本 ,采用石蜡包埋切片 ,HE染色光镜观测。 结果 (1)软骨细胞的大小随胎龄增长而增大 ,其密度随胎龄增长而减小 ,两者在 7～ 8月龄变化明显。(2 )鼻肌 4个月出现横纹 ,6个月横纹明显 ,大多数胞核位于肌膜下。(3)鼻皮肤表皮的角化、表皮嵴的发育及附属器的出现均有恒定的时间。 结论 (1) 7～ 8月龄是胎儿鼻软骨发育重要 (旺盛 )时期。 (2 )鼻皮肤的成熟程度与胎龄间有严格的对应关系
Objective To investigate the developmental rules of fetal nasal cartilage, nasal muscle and nasal skin and to provide information on nasal embryo development and age anatomy. Methods Fetal free cartilaginous nasal specimens from 39 cases of 3 to 10 months old were collected and paraffin embedded sections were used for observation. Results (1) The size of chondrocytes increased with the increase of gestational age, and the density of chondrocytes decreased with the increase of gestational age. Both of them varied significantly from 7 to 8 months old. (2) There were horizontal stripes in the nasal muscle for 4 months and obvious stripes in 6 months. Most nuclei were located under the sarcolemma. (3) Nasal skin epidermis keratosis, the development of epidermal ridges and appendages have a constant time. Conclusion (1) 7 ~ 8 months of age is an important fetal nasal cartilage development (exuberant) period. (2) the degree of maturity of the nasal skin and gestational age have a strict correspondence between