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随着我国农业的飞跃前进,有机磷农药的大量生产及使用,在临床上中毒病人是逐渐发现的,既往主要使用大量的阿托品治疗。由于阿托品不能解除有机磷对酶的抑制,仅能对抗中毒时的毒蕈鹼样作用和部分中枢神经系的毒性表现,对菸鹼样作用则无效,因而就不能解除中毒致死的主要原因,同时阿托品对抗乙(?)胆鹼时且需用量往往超过常用量的十至百倍,易引起副作用或中毒,且需频繁注射,对搶救处理颇为不便,故对疗效大,副作用及毒性小的药物迫切需要。PAMB即其中之一。国外曾有少
With the rapid development of agriculture in our country, the mass production and use of organophosphorus pesticides have gradually been found in patients with clinical poisoning. In the past, a large number of atropine treatments were mainly used. As atropine can not lift the inhibition of organophosphorus enzyme, only against muscarinic poisoning and part of the central nervous system toxicity, nicotine-like effect is invalid, and thus can not be relieved of the main cause of poisoning and death, at the same time Atropine against B (?) Choline and the amount required often more than the commonly used amount of ten to hundred times, easy to cause side effects or poisoning, and frequent injections, the treatment is quite inconvenient, so the curative effect, side effects and toxicity of small drugs urgent need. PAMB is one of them. There have been less foreign countries