已经证明半合成的脂肪栓基质在贮藏期中,其晶型由非稳定性A型逐步转化成比较稳定的B型。随之制剂发生性质改变,如熔点增加,软化时间延长,药物释放减少等等。由于栓剂中含有各种理化性质和各种浓度的药物,而药物与基质间会发生一定程度的作用,所以有必要阐明药物对栓剂性质的影响。 It has been demonstrated that the semisynthetic fat-plug matrix is ​​gradually transformed from a non-stabilized A form into a more stable form B during storage. The resulting formulation changes in nature, such as increased melting point, softening time, reduced drug release and so on. Because suppositories contain a variety of physicochemical properties and concentrations of drugs, and the drug will have a certain degree of role between the substrate, it is necessary to clarify the impact of drugs on the nature of the suppository.