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目的:研究痛风宁对急性痛风的抗炎机理。方法:24只大鼠随机分成3组:正常组、模型组、中药组。前两组灌胃蒸馏水,后一组灌胃痛风宁溶液,于第3天将尿酸钠溶液注入后两组各大鼠右侧踝关节腔造模,72h后观察受试关节周围软组织及血浆PGE_2、6-K-PGF_(1α)。结果:中药组受试关节周围软组织PGE_2、6-K-PGF_(1α)。及血浆6-K-PGF_(1α)明显低于模型组。结论:痛风宁通过降低PGE_2、PGI_2起抗炎作用。
Objective: To study the anti-inflammatory mechanism of Tongfengning on acute gout. Methods: Twenty-four rats were randomly divided into three groups: normal group, model group, and traditional Chinese medicine group. The first two groups administrated distilled water, and the latter group was given Tongfengning solution. After the injection of sodium urate solution on the third day, the right ankle joint cavity of the rats of each group was modeled. After 72 hours, the soft tissues around the joints and plasma PGE2 were observed. , 6-K-PGF_(1α). Results: In the traditional Chinese medicine group, PGE_2 and 6-K-PGF_(1α) were detected around the joints. And plasma 6-K-PGF_ (1α) was significantly lower than the model group. Conclusion: Tongfengning has anti-inflammatory effect by reducing PGE 2 and PGI 2 .