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目的:观察人类免疫缺陷病毒(HIV)和结核病与艾滋病双重感染患者在使用抗结核药物治疗后的效果。方法:选取我院2016年1月到2017年1月治疗的并发肺结核的HIV感染与AIDS患者90例,所有患者都属于初治患者,使用的抗结核药物治疗是3-H-R-E-Z/6H-R。将患者在治疗过程中临床症状和抗结核治疗效果分别记录。结果:所有患者中,有47例患者在治疗前CD4~+T淋巴细胞数不多于200个/mm~3;有43例患者超过200个/mm~3。43例≥200个/mm~3患者在使用抗结核药物治疗后,其病灶吸收情况表现良好,且临床症状也得到了好转,不存在死亡患者;治疗前CD4~+T淋巴细胞数不多于200个/mm~3的47例患者在经过抗结核的治疗后,有42例患者的临床情况得到了好转,死亡患者有5例。两组患者数据比较,差异具有统计学意义,P<0.05。结论:若HIV感染和AIDS与结核病患者的CD4~+T淋巴细胞数超过200个/mm~3,则经过抗结核治疗后能够获得更佳的效果。
Objective: To observe the effect of anti-TB drug treatment in patients with double-infection of human immunodeficiency virus (HIV) and tuberculosis and AIDS. Methods: Totally 90 HIV-infected and AIDS patients with pulmonary tuberculosis who were treated in our hospital from January 2016 to January 2017 were enrolled in this study. All patients were newly-treated patients. The anti-TB drug used was 3-H-R-E-Z / 6H-R. The patients in the course of treatment of clinical symptoms and anti-TB treatment were recorded. Results: Of all patients, 47 had CD4 ~ + T lymphocyte counts of no more than 200 / mm ~ 3 before treatment; 43 patients had more than 200 / mm ~ 3.43 cases ≥200 / mm ~ 3 patients using anti-TB drugs, the absorption of the lesions performed well, and the clinical symptoms have been improved, there is no death patients; before treatment CD4 ~ + T lymphocyte count of not more than 200 / mm ~ 3 47 After treatment with anti-TB drugs in 42 patients, the clinical condition of 42 patients was improved, and 5 patients died. The two groups of patients data, the difference was statistically significant, P <0.05. Conclusion: If the number of CD4 ~ + T lymphocytes in HIV infection and AIDS and tuberculosis patients exceeds 200 / mm ~ 3, better results will be obtained after anti-TB treatment.