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目的探讨ＳＰＥＣＴ腮腺功能测定评价鼻咽癌患者不同设野放射治疗后腮腺功能损伤情况的可行性．方法选取 ３１例鼻咽癌患者作研究对象，行单纯放射治疗，其中 ２０例行双耳前野放疗， １１例行双耳前野加鼻前野放疗．患者在放疗前和放疗后均用ＳＰＥＣＴ检测其腮腺功能．结果常规鼻咽双耳前野加鼻前野放射治疗和双耳前野放射治疗的腮腺摄取功能极度损伤率分别为４．５％（１／２２）和２７．５％（１１／４０）；排泌功能极度损伤率分别为３６．４％（８／２２）和６５．０％（２６／４０），两对照组比较均有统计学差异（ｐ＜０．０５）．结论ＳＰＥＣＴ腮腺功能测定是评价鼻咽癌患者放射治疗后腮腺功能损伤程度的敏感、适用的方法；腮腺损伤以排泌功能损伤为主，放射剂量愈大，腮腺的摄取和排泌功能损伤愈严重．
Objective To investigate the feasibility of using SPECT parotid gland function to evaluate parotid gland function after radiation therapy in different nasopharyngeal carcinoma patients. Methods Totally 31 patients with nasopharyngeal carcinoma were enrolled in this study. Radiotherapy was performed in 20 patients. Patients before and after radiotherapy were detected by SPECT parotid function. Results The rates of extreme parotid ingestion were significantly lower in conventional anterior and posterior nasal area plus nasal field irradiation and binaural anterior chamber radiotherapy (4.5% (1/22) and 27.5% (11/40), respectively) The rates of severe injury were 36.4% (8/22) and 65.0% (26/40), respectively. There were significant differences between the two control groups (p <0.05). Conclusions The parotid gland function test is a sensitive and appropriate method to evaluate the degree of parotid gland function after radiotherapy in patients with nasopharyngeal carcinoma. Parotid gland injury is mainly excretory function injury. The greater the radiation dose, the more severe the injury of parotid gland function and uptake and excretion .