血管内皮生长因子(Vascular endothelial growth factor, VEGF)最早于1989年由Ferrara等从牛脑垂体呈状胶质细胞体外培养液中分离并提纯出的一种糖蛋白,可特异性地促进血管内皮细胞生长,故称为血管内皮生长因子。后发现血管通透因子(VPF)也具有VEGF的活性,经蛋白质测序和基因分析发现,二者实际为同一基因不同剪切方式所产生的系列产物,故又称为血管通透性因子。 Vascular endothelial growth factor (VEGF) was first isolated and purified from the bovine pituitary astrocytes in vitro by Ferrara et al. In 1989 and can specifically promote the proliferation of vascular endothelial cells Growth, it is called vascular endothelial growth factor. After the discovery of vascular permeability factor (VPF) also has the activity of VEGF, protein sequencing and gene analysis found that the two actually produced by the same gene different shear series of products, it is also known as vascular permeability factor.