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在上海市(1986年10月～1987年9月)的75756例围生儿出生缺陷的监测中发现,有缺陷者1012例,发生率为13.36‰,与遗传有关的缺陷占65.22％,发生率为8.71‰。其中多基因遗传性畸形最多,其次为单基因遗传性及染色体病,发生率分别为总数的4.37‰、3.58‰和0.77‰。多数畸形随产妇育龄增高而有增加倾问,以多发性畸形及Down综合征为显著。产妇育龄≥35岁,畸形的发生率显著上升。建议年龄≥35岁的孕妇,以及曾分娩过缺陷儿的孕妇,均需作产前诊断监护,如有不良妊娠,应予终止,以利优生。
In Shanghai (October 1986 ~ September 1987) 75,756 cases of perinatal birth defects monitoring found that 1012 cases of defective, the incidence was 13.36 ‰, genetic defects accounted for 65.22%, the incidence 8.71 ‰. Among them, polygenes had the most common deformity, followed by single-gene heredity and chromosomal diseases, the incidence rates were 4.37 ‰, 3.58 ‰ and 0.77 ‰, respectively. The majority of deformities with the increase of childbearing age have increased ask, with multiple deformities and Down syndrome was significant. Maternal age ≥35 years old, the incidence of deformity increased significantly. Proposed age ≥ 35-year-old pregnant women, as well as pregnant women who have had birth defects, are required for prenatal diagnosis and custody, if adverse pregnancy, should be terminated to facilitate eugenics.