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目的研究愈溃单向释药膜中有效成分胡黄连苷与龙脑的体外释放机制。方法采用HPLC、GC测定愈溃膜中胡黄连苷、龙脑的体外释放度,并将累积释放量分别用零级方程、一级方程、Higuchi方程、Retiger-Peppas(R-P)方程拟合,分析二者的体外释药模式;采用相似因子法(f2)评价二者能否达到均衡释放。结果胡黄连苷、龙脑的体外释放曲线均接近一级动力学方程;愈溃膜中胡黄连苷与龙脑的相似因子大于50%。结论愈溃膜中有效成分胡黄连苷与龙脑能够达到均衡释放。
OBJECTIVE To study the in vitro release mechanism of picroside and borneol from the active ingredient unilaterally released membrane. Methods HPLC and GC were used to determine the in vitro release of picroside and borneol from the ulcerous membranes. The cumulative release was fitted by the zero order equation, the first order equation, the Higuchi equation and the Retiger-Peppas (RP) equation, respectively Both in vitro release patterns; using similar factor method (f2) evaluation of whether the two reached a balanced release. Results The release curves of picroside and borneol in vitro were close to the first-order kinetic equation. The similar factors of picrotoxin and borneol were more than 50%. Conclusion The more effective ingredients in ulcerated membrane picrorhiza and borneol can achieve a balanced release.