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【目的】探讨胰岛素治疗与2型糖尿病（T2DM ）患者继发恶性肿瘤的关系。【方法】回顾性分析2003年1月至2007年12月在汕头大学第一、二附属医院住院的8051例T2DM患者临床资料。根据是否使用胰岛素治疗将患者分为两组：观察组（胰岛素治疗组，792例）和对照组（非胰岛素治疗组，7259例），比较两组人群继发恶性肿瘤患病情况。【结果】纳入本研究8051例T2DM 患者中，观察组糖尿病病程较对照组长，合并恶性肿瘤发生率低，且两组相比较差异有显著性（χ2＝6．720，P ＜0．01）。 T2DM 患者恶性肿瘤患病风险与男性呈负相关（OR＝0．71，95％ CI为0．50～0．86），与年龄（OR＝1．72，95％ CI为1．39～1．86）和吸烟史（OR＝2．36，95％ CI为1．65～3．82）呈正相关，和胰岛素治疗无关（ P ＝0．72，OR＝0．71，95％ CI为0．52～1．10）。【结论】胰岛素治疗与T2DM继发恶性肿瘤发病风险无关。“,”[Objective]To explore the correlation between insulin therapy and secondary malignant tumor in patients with type 2 diabetes mellitus(T2DM ) .[Methods] Clinical data of 8051 T2DM in first and second affiliated hospital of Shantou university from Jan .2003 to Dec .2007 were analyzed retrospectively .According to insulin therapy or not ,all patients were divided into case group(insulin therapy group ,n=792) and control group(non-insulin therapy group ,n=7259) .The prevalence of secondary malignant tumor was compared be-tween two groups .[Results] Among 8051 T2DM patients in the study ,the course of diabetic mellitus in case group was longer than that in control group ,while the incidence of malignant tumor was lower ,and there was significant difference between two groups(χ2 =6 .720 ,P <0 .01) .The prevalence risk of malignant tumor in T2DM patients was negatively related with male (OR= 0 .71 ,95% CI= 0 .50~0 .86) ,but positively related with age(OR=1 .72 ,95% CI=1 .39~1 .86) and smoking history(OR=2 .36 ,95% CI=1 .65~3 .82) ,and had no correlation with insulin therapy ( P=0 .72 ,OR=0 .71 ,95% CI为0 .52~1 .10) .[Conclusion] Insulin thera-py is not associated with the prevalence risk of secondary malignant tumor in T 2DM .