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【目的】测定手术治疗前Graves病甲状腺功能亢进（甲亢）患者血清甲状腺过氧化物酶抗体（ T POAb）和甲状腺球蛋白抗体（ TGA b）水平，探讨其在手术治疗后与甲状腺功能减退（甲减）发生的关系。【方法】根据手术治疗前TPOA b、TGA b的检测结果，将198例患者分成3组：双阴组12例，单阳组32例，双阳组154例，比较各组间甲减的发生率。再将双阳组的154例患者，按TPOA b、TGA b滴度水平的高低分成3组：A组79例，B组65例，C组10例，进一步探讨手术治疗前TPOA b、TGA b滴度水平的高低与甲减的关系。【结果】手术治疗后甲减发生率差异有统计学意义（ P＜0．005）。双阳组的154例患者，其TPOAb、TGA b滴度水平高低与甲减发生率相关（ P＜0．005）。【结论】TGAb、TPOA b滴度水平的检测对于甲亢手术治疗后甲减的预测有指导作用。“,”[Objective]To measure serum levels of thyroid peroxidase antibody (TPOAb ) and thyroglobulin antibody (TGAb) in patients with Graves hyperthyroidism before surgery ,and to explore their correlation with the incidence of hy-pothyroidism after surgery .[Methods]According to the results of TPOAb and TGAb ,198 patients were divided into both negative TPOAb and TGAb group( n=12) ,positive TPOAb or TGAb group( n = 32) and both positive TPOAb and TGAb( n=154) .According to the titer levels of TPOAb and TGAb ,154 patients with both positive TPOAb and TGAb were also divided into group A ( n=79) ,group B( n=65) and group C( n=10) .The correlation of the titer levels of TPOAb and TGAb with hypothyroidism before the operation was further discussed .[Results] There was significant difference in the incidence of hypothyroidism after the operation among three groups ( P<0 .005) .Among 154 patients of both positive TPOAb and TGAb group ,the titer levels of TPOAb and TGAb were related with the incidence of hyperthy-roidism( P<0 .005) .[Conclusion] The detection of serum levels of TPOAb and TGAb is of significance for predicting the incidence of hypothyroidism after surgery .