目的　研究可手术乳腺癌给予CTF方案新辅助化疗的安全性、近期疗效 ,以及对手术方式的影响。方法　 138例Ⅱ、Ⅲ期乳腺癌患者用CTF方案化疗 3周期。结果　完全缓解 2 0例 ,部分缓解 10 4例 ,总有效率 89.9%。毒性反应主要为脱发、轻度骨髓抑制、胃肠道反应 ,极少肝功能损伤及口腔溃疡 ,经对症处理后缓解。结论　CTF方案术前化疗可以明显缩小原发灶 ,简化手术 ,提高患者术后的生活质量 ,其毒副作用很小 ,可以耐受 Objective To study the safety and efficacy of neoadjuvant chemotherapy for CTF regimen for operable breast cancer and its impact on the surgical approach. Methods 138 patients with stage Ⅱ, Ⅲ breast cancer patients with CTF chemotherapy 3 cycles. The results of complete remission 20 cases, partial remission 104 cases, the total effective rate 89.9%. Toxicity mainly alopecia, mild myelosuppression, gastrointestinal reactions, minimal liver damage and oral ulcer, symptomatic relief after symptomatic treatment. Conclusion CTF regimen preoperative chemotherapy can significantly reduce the primary tumor, simplify the operation and improve the quality of life of patients with little side effects, can be tolerated