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目的 探讨阿奇霉素对不稳定型心绞痛的影响。方法 应用酶联免疫法检测 10 0例不稳定型心绞痛患者血清肺炎衣原体 (CP)特异性抗体IgG。 76例肺炎衣原体抗体IgG阳性者随机分为治疗组 38例和对照组 38例 ,对照组给予扩张冠脉、抗凝等常规治疗 ,治疗组在常规治疗的基础上应用阿奇霉素。结果 治疗组 12～ 18个月内因不稳定型心绞痛再入院、急性心肌梗死和死亡的发生率均明显低于常规治疗的对照组 ,其中 ,不稳定型心绞痛住院的发生率两组比较有显著差异 (P <0 .0 5 )。结论 阿奇霉素可改善CP感染的不稳定型心绞痛的预后 ,减少心血管恶性事件的发生
Objective To investigate the effect of azithromycin on unstable angina pectoris. Methods Serum CP (Chlamydia pneumoniae) specific IgG was detected by enzyme-linked immunosorbent assay in 100 patients with unstable angina pectoris. Seventy-six patients with positive Chlamydia pneumoniae antibody IgG were randomly divided into treatment group (38 cases) and control group (38 cases). The control group was given conventional therapy such as dilation of coronary artery and anticoagulation. The treatment group received azithromycin on the basis of routine treatment. Results The incidence of acute myocardial infarction and death was significantly lower in the treatment group within 12 to 18 months due to unstable angina re-admission, in which the incidence of unstable angina pectoris was significantly different between the two groups (P <0. 05). Conclusion Azithromycin can improve the prognosis of CP-induced unstable angina and reduce the occurrence of cardiovascular events