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目的通过检测血清果糖胺(GSP)水平,评价该指标在糖尿病诊断及诊疗随访中的临床价值及意义。方法采用全自动生化分析仪对160例糖尿病患者及80名健康对照者分别测定空腹血糖、血清果糖胺,糖尿病患者6个月测HbA1c,低GSP者加测夜间及餐前血糖。结果GSP:正常对照组(2.40±0.22)mmol/L,糖尿病高血糖患者组(3.48±0.24)mmol/L,糖尿病低血糖患者组(0.96±0.40)mmol/L。经t检验糖尿病者与正常对照组有明显性差异(P<0.01)。结论GSP可以做为糖尿病诊断及随访简单、有效的辅助指标。有利于发现夜间及无症状低血糖,有利于糖尿病持续、稳定、安全达标。
Objective To evaluate the clinical value and significance of detecting serum fructosamine (GSP) in the diagnosis and follow-up of diabetes mellitus. Methods Fasting blood glucose (FBG), serum fructosamine and diabetes mellitus were measured in sixty patients with diabetes mellitus and eighty healthy controls by using an automatic biochemical analyzer. Six months later, HbA1c and low GSP were measured. Results GSP was 2.40 ± 0.22 mmol / L in normal control group, 3.48 ± 0.24 mmol / L in diabetic hyperglycemia group and 0.96 ± 0.40 mmol / L in diabetic hypoglycemia group. There was a significant difference between t-test and control group (P <0.01). Conclusion GSP can be used as a simple and effective auxiliary indicator for the diagnosis and follow-up of diabetes mellitus. Is conducive to the discovery of night and asymptomatic hypoglycemia, is conducive to diabetes sustained, stable, safe compliance.