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为阐明多次发生＋Ｇｚ致意识丧失对脑的影响及其机制，观察了反复下体负压（ＬＢＮＰ）致意识丧失对大鼠血脑屏障（ＢＢＢ）通透性的影响。雄性ＳＤ大鼠，麻醉后置于－４．０ｋＰａ的下体负压舱内，至脑电波消失２ｍｉｎ后恢复常压。分别于一次和三次ＬＢＮＰ作用后１ｈ利用硝酸镧示踪法观察ＢＢＢ通透性的变化。一次ＬＢＮＰ致意识丧失组大鼠脑皮层组织变化不明显；三次ＬＢＮＰ致意识丧失组大鼠脑皮层组织中大部分毛细血管内皮细胞间的紧密连接开放，镧颗粒弥漫性地分布于神经细胞间隙和轴突周围，脑组织水含量较对照组显著升高（Ｐ＜０．０５）。结果提示，反复三次ＬＢＮＰ致意识丧失可引起大鼠血脑屏障通透性显著增加，这可能在脑水肿的发生发展中起重要作用
To clarify the effect of + Gz-induced loss of consciousness on the brain and its mechanism, the effects of LBNP-induced loss of consciousness on permeability of the blood-brain barrier (BBB) in rats were observed. Male Sprague-Dawley rats were anesthetized and placed in the lower negative pressure chamber of -4.0 kPa, and the pressure was restored to 2 minutes after the brainwave disappeared. The change of BBB permeability was observed by lanthanum nitrate tracing method 1 h after the first and third LBNP respectively. Once LBNP-induced loss of rat brain cortex tissue change was not obvious; three LBNP-induced loss of rat cerebral cortex tissue most of the capillary endothelial cell tight junctions open, diffuse distribution of lanthanum particles in the nerve cell gap and Around the axons, the water content of brain tissue was significantly higher than that of the control group (P <0.05). The results suggest that repeated LBNP-induced loss of consciousness can cause a significant increase of BBB permeability in rats, which may play an important role in the development of brain edema