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目的 掌握皖南山区钩体病的流行规律和疫情发展趋势。方法 分析流行病学、血清学 (MAT)、病原学。结果 皖南山区是我省钩体病重疫区 ,病例数占近十年总数 92 .90 % ,且疫情稳定 ,季节明显 ,是典型的稻田型钩体病疫区。从宿主动物和传染源分离的钩端螺旋体分属 8群 9型 ,鼠肾PCR检测感染率为1 1 .67% (1 4 / 1 2 0 )。黄山区鼠血清学分属 3群 4型 ,并从黑线姬鼠肾中首次分获钩体棉兰型一株。牛血清检测感染率为 3661 .2 9%分属 8群 9型 ,其中赛罗群占 33 .31 4 2 .1 1 %。自然人群MAT总感染率为 2 1 .2 4 %分属 7群 7型 ,其中赛罗群占 42 .70 % ,黄疸出血群仅为 1 9.1 0 %。而 1 992年之前自然人群血清学分属 7群 ,其中黄疸出血群占 2 2 .75 % ,犬和七日热群各占 1 7.96 % ,病人血清检测结果 91 .80 %为黄疸出血群。结论 皖南山区钩体病菌型出现更迭 ,为制定防治对策提供科学依据
Objective To understand the prevalence of leptospirosis and development trend of epidemic situation in mountain area of Southern Anhui. Methods Analysis of epidemiology, serology (MAT), etiology. Results The southern Anhui mountainous area was the leptospirosis in our province. The number of cases accounted for 92.90% of the total in recent ten years. The epidemic situation was stable and the season was obvious. It was a typical paddy-type leptospirosis. Leptospira isolates from host animals and sources of infection belonged to 8 groups and 9 strains. The infection rate of rat kidney PCR was 11.67% (14/120). Huangshan rat serology belong to 3 groups of 4 type, and from the black Apodemus kidney for the first time won a hook medlar type. The detection rate of bovine serum was 3661.29% belonged to 8 groups and 9 types, including 33.31 4 2 .1 1%. The rate of MAT in natural population was 21.2%, which belonged to 7 groups and 7 groups, of which, 42.7% were in Cerro group and 1.90% in hemorrhagic jaundice group. Before1992, the natural population belonged to 7 groups, of which 22.5% were jaundiced, 17.96% were canine and 7-day fever, and 91.80% were seropositive for jaundice. Conclusion The pathogenic bacteria of leptospirosis in mountain area of Southern Anhui Province have been changed, providing a scientific basis for making prevention and control measures