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目的 探讨肾移植后应用他克莫司 (FK5 0 6 )的方法、剂量、疗效及副作用。方法 30例尸肾移植患者术后应用他克莫司 ,临床观察 3个月 ,监测血中他克莫司的浓度和副作用。结果 30例患者术后肾功能均恢复正常 ,在应用他克莫司的观察期内无排斥反应发生 ;血中他克莫司的浓度 ,3例为 5～ 7μg/L ,2 5例为 8～ 15 μg/L ,2例为 32～ 38μg/L ;他克莫司的副作用主要为骨髓抑制和血糖升高。结论 他克莫司是一种强效免疫抑制剂 ;用药要个体化 ,不应片面强调他克莫司的血药浓度 ;他克莫司适合慢性肝炎或肝功能损害者使用 ;突出副作用为骨髓抑制和血糖升高
Objective To investigate the method, dose, efficacy and side effects of tacrolimus (FK506) after renal transplantation. Methods Tacrolimus was administered to 30 patients with postoperative corpse renal transplantation. The clinical observation was 3 months. The concentration and side effects of tacrolimus in blood were monitored. Results The renal function of all 30 patients returned to normal. No rejection occurred during the observation period with tacrolimus. The blood concentrations of tacrolimus were 3 to 5 μg / L and 25 to 8 ~ 15 μg / L, 2 cases of 32 ~ 38μg / L; the main side effects of tacrolimus are myelosuppression and elevated blood sugar. Conclusion Tacrolimus is a potent immunosuppressive agent; medication should be individualized and the plasma concentration of tacrolimus should not be overemphasized; tacrolimus is appropriate for chronic hepatitis or impaired hepatic function; and the side effect is bone marrow Inhibition and elevated blood sugar