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目的 了解实行加碘盐 3周年以来以广州市区孕产妇及其新生儿碘营养状况。方法 用砷铈接触法测定 6 7名待产孕妇尿碘 ,用放射免疫分析法测定其孕妇所产新生儿脐带血甲状腺素 (T4)、促甲状腺激素(TSH)。结果 待产孕妇尿碘中位数为 741.9μg/L,<10 0 μg/L 者仅占 3.2 %。新生儿脐带血清 T4为 (149.6 9±5 4.5 6 ) nmol/L,在正常范围 (5 4～ 174nmol/L)者占 71.2 % ,超过 174nm ol/L 者占 2 8.8%。脐带血清 TSH<5 m U/L 者占 89.4% ,TSH>5 m U/L 者占 10 .6 % ,其中女婴与男婴相比 ,差异有显著意义 (P <0 .0 2 5 )。在 TSH>5 m U/L 者中有 5 7.1%的人尿碘含量 >10 0 0 μg/L。孕妇妊娠反应 <3个月者 T4超过正常值上限者较多 ,与 >3个月者相比差异有显著意义 (P <0 .0 5 )。孕妇问卷调查表明 ,孕妇常吃海产品占 2 5 .4% ,常吃海带、紫菜占12 .7% ,体重增加 10 kg以上者占 46 .0 %。结论 广州市区孕产妇及新生儿碘营养状况良好 ,尿碘较高 ,较多人有碘过剩现象 ,提示应注意防止高碘问题。
Objective To understand the iodine nutrition status of pregnant women and their newborns in downtown Guangzhou since the 3rd anniversary of iodized salt. Methods Arsenic and cerium contact method was used to determine the urinary iodine in 67 pregnant women who were to be pregnant. The neonatal umbilical cord blood thyroid hormone (T4) and thyrotropin (TSH) were measured by radioimmunoassay. Results The median urinary iodine of pregnant women to be pregnant was 741.9μg / L, only <3.2% when <100 μg / L. The neonatal umbilical cord serum T4 was (149.6 9 ± 5 4.56) nmol / L, accounting for 71.2% in the normal range (54-174 nmol / L) and 8.8% in the neonates with 174 nmol / L. Umbilical cord serum TSH <5 mU / L accounted for 89.4%, TSH> 5 mU / L accounted for 10.6%, of which baby girls compared with the male infants, the difference was significant (P <0. 025) . Fifty-one percent of those with TSH> 5 mU / L had urinary iodine levels> 10 0 μg / L. Pregnant women with pregnancy reaction <3 months T4 more than the upper limit of normal more, compared with> 3 months, the difference was significant (P <0. Survey of pregnant women showed that pregnant women eat seafood accounted for 25.4%, eat kelp, seaweed accounted for 12.7%, weight gain of 10 kg or more accounted for 46.0%. Conclusion Guangzhou maternal and neonatal iodine nutritional status is good, urinary iodine higher, more people have iodine excess, suggesting that attention should be paid to prevent high iodine.