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作者采用6～7周龄体重23～24g 的雌性无毛小鼠,以月桂氮酮(azone,AZ)作为皮肤增透剂,利用皮肤膏药的控释性能,将无环鸟苷(ACV)以定量控制方式透皮释放,以一种新的模型和方法评价局部给药时抗病毒治疗的有效性。皮肤膏药由(1)背衬;(2)垫圈;(3)O-形环;(4)柄;(5)控释膜依次粘合在一起,中间形成贮药室,内含可供7天恒速释放的 ACV 混悬液。控释膜由交联聚合水凝胶构成,不同化学成分的膜水合值不同,水合值越高,通透性越大,并以此调节皮肤膏药的释放率。将膏药置于含5～10ml 0.1mol/L 醋酸
The authors used 6-7 weeks old female body weight 23 ~ 24g hairless mice with Azone Azone (AZZ) as skin penetration enhancer, the use of skin plaster controlled release properties of acyclovir (ACV) Transdermally delivered in a controlled manner, a new model and method was used to evaluate the effectiveness of antiviral therapy at topical administration. Skin plaster consists of (1) backing; (2) washer; (3) O-ring; (4) handle; (5) controlled release film in turn glued together to form a drug storage chamber, Days constant release of ACV suspension. Controlled release membrane is composed of cross-linked polymeric hydrogel, different hydration of different chemical composition of the membrane, the higher the hydration value, the greater the permeability, and thus regulate the release rate of the skin plaster. The plaster is placed in 5 ~ 10ml 0.1mol / L acetic acid