已知性别和性激素可影响免疫应答的性质,对寄生原虫感染的易感性由受性激素影响的免疫学机制所决定。本文作者监测了缺乏淋巴细胞的SCID小鼠感染刚地弓形虫的过程,分析了它对感染的先天性免疫应答情况。在雌性和雄性SCID小鼠经口感染刚地弓形虫的组织包囊后,测定了死亡率、脑组织的病理学变化及虫荷,并测定血浆中循环IL-12和IFN-γ水平,比较该结果与先天性免疫应答激活的关系。 Sex and sex hormones are known to affect the nature of the immune response and the susceptibility to parasitic protozoal infections is determined by the immunological mechanisms that are affected by sex hormones. The authors monitored the process of T. gondii infection in SCID mice lacking lymphocytes and analyzed their innate immune response to infection. After female and male SCID mice were orally infected with Toxoplasma gondii tissue, the mortality, pathological changes of brain tissue and worm burden were measured. The levels of circulating IL-12 and IFN-γ in plasma were also measured. The result is related to the activation of the innate immune response.