论文部分内容阅读
为探讨复方丹参滴丸(DSP)对心肌损伤的保护作用机制,将120只大鼠随机分为4组:异丙肾上腺索(ISO)损伤组、DSP 保护组、DSP+ISO 组及正常对照组。应用 ISO 腹腔内注射造成心肌缺血损伤,测定大鼠血清及心肌组织中脂质过氧化物丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性及血浆中内皮素(ET)和血清中一氧化氮(NO)含量的变化。结果表明,DSP 保护组血浆中 NO 含量升高,与正常对照组差异有显著性;DSP保护组注射 ISO 后 MDA、SOD、ET 及 NO 变化程度明显小于单纯 ISO 组,差异有显著性。结论:复方丹参滴丸具有良好的抗急性心肌缺血损伤作用,其作用机制与抗自由基及血管内皮保护效应密切相关。
To investigate the protective mechanism of compound Danshen Dripping Pills (DSP) on myocardial injury, 120 rats were randomly divided into 4 groups: isoproterenol (ISO) injury group, DSP protection group, DSP+ISO group and normal control group. . Myocardial ischemic injury was induced by intraperitoneal injection of ISO. Lipid peroxide (MDA) content, superoxide dismutase (SOD) activity, and plasma endothelin (ET) were measured in rat serum and myocardial tissue. Changes in serum nitric oxide (NO) content. The results showed that plasma levels of NO in the plasma of the DSP-protected group were significantly higher than those in the normal control group. The levels of MDA, SOD, ET, and NO in the DSP-protected group were significantly smaller than those in the ISO alone group. The difference was statistically significant. Conclusion: Compound Danshen Dripping Pills have a good anti-acute myocardial ischemic injury, and its mechanism of action is closely related to the anti-free radical and endothelial protective effects.