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为探讨周期素 D1(Cyclin D1)蛋白在乳腺癌中的表达及其临床意义 ,作者采用免疫组化 L SAB法对 110例乳腺癌标本进行了 Cyclin D1蛋白的检测。结果显示 :本组病例的 Cyclin D1蛋白表达阳性率为 74.5 5 %(82 / 110 ) ;生存时间≤ 5年及≥ 10年者 ,其 Cyclin D1蛋白表达阳性率分别为 96 .2 2 % (5 1/ 5 3)和 40 .5 4% (15 / 37) ;Cyclin D1蛋白过度表达与乳腺癌的临床分期、组织学分级、腋窝淋巴结转移有关。由此揭示 Cyclin D1蛋白的过度表达是判断乳腺癌患者预后的一项重要指标。
To investigate the expression of Cyclin D1 protein in breast cancer and its clinical significance, the authors used immunohistochemical L SAB method to detect Cyclin D1 protein in 110 breast cancer specimens. The results showed that the positive rate of Cyclin D1 protein expression was 74.55% (82/110) in this group of patients, and the positive rate of Cyclin D1 protein expression was 96.22% (5 years for survival time ≤ 5 years and ≥ 10 years) (5 1/3 3) and 40.5% (15/37); Cyclin D1 overexpression was associated with clinical stage, histological grade, and axillary lymph node metastasis in breast cancer. This reveals that overexpression of Cyclin D1 protein is an important indicator to determine the prognosis of breast cancer patients.