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目的:探讨核RNA输出因子3(nuclearRNA export factor 3,NXF3)在肝细胞肝癌(HCC)患者中的表达及意义。方法:采用免疫组织化学法检测96例HCC患者的癌组织及癌旁组织中NXF3的表达。采用Cox比例风险模型与Kaplan-Meier法分析NXF3与患者的临床和病理特征及生存期的关系。结果:NXF3在HCC患者癌组织中的表达显著高于癌旁组织(P<0.001),且在合并有肝硬化的HCC患者中显著高表达[比值比(odds ratio,OR)为0.018,95%可信区间(confidence interral,CI)为1.2~10.9]。与癌组织中NXF3低表达HCC患者相比,NXF3高表达HCC患者总体生存率与无瘤生存率均较低(P=0.022和P=0.014)。采用Cox比例风险模型对影响HCC患者预后的临床和病理特征进行单因素与多因素分析,结果均表明,NXF3为HCC患者的独立危险因素。与癌组织中NXF3低表达的患者相比,NXF3高表达的患者的病死率和复发率更高(OR=3.2,P=0.006;OR=2.5,P=0.008)。结论;NXF3在HCC患者癌组织中呈高表达,并与HCC患者的总体生存率以及肿瘤复发有关,可以作为判断HCC患者肝切除术后的预后指标。
Objective: To investigate the expression of nuclear RNA export factor 3 (NXF3) in hepatocellular carcinoma (HCC) patients and its significance. Methods: Immunohistochemical method was used to detect the expression of NXF3 in 96 cases of HCC patients and adjacent tissues. Cox proportional hazards model and Kaplan-Meier method were used to analyze the relationship between the clinical and pathological features and survival of patients with NXF3. Results: The expression of NXF3 in HCC patients was significantly higher than that in adjacent non-cancerous tissues (P <0.001), and significantly higher in HCC with cirrhosis [odds ratio (OR) was 0.018, 95% The confidence interval (CI) ranged from 1.2 to 10.9]. The overall survival rate and tumor-free survival rate of NXF3-overexpressing HCC patients were lower than those of HCC patients with low expression of NXF3 in cancerous tissue (P = 0.022 and P = 0.014). Univariate and multivariate analysis of the clinical and pathological features affecting the prognosis of patients with HCC using the Cox proportional hazards model showed that NXF3 was an independent risk factor for HCC. Patients with high expression of NXF3 had a higher mortality and relapse rate (OR = 3.2, P = 0.006; OR = 2.5, P = 0.008) than those with low expression of NXF3 in cancerous tissues. Conclusions; NXF3 is highly expressed in the tissues of HCC patients and is related to the overall survival rate and tumor recurrence in patients with HCC. It may be used as a prognostic indicator in determining the prognosis of patients with HCC after liver resection.