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目的探讨胃癌组织和癌旁组织中PTEN基因的表达及其对患者预后的影响。方法收集1991年1月至1996年12月间收治的113例胃癌单纯手术治疗患者的临床病理资料和术后生存随访资料,将癌组织与相对应癌旁组织制作组织芯片,通过免疫组化的方法,分别获得PTEN基因在其中的表达评分。分析PTEN基因表达与患者临床病理指标及预后之间的关系。结果 113例患者中,最终获得108例患者的有效信息,PTEN基因在108例胃癌患者癌组织中的表达水平明显低于癌旁组织(P<0.001)。PTEN基因变化与患者年龄、组织浸润肿瘤侵袭深度、淋巴结转移率、远处转移率和TNM分期等方面差异无统计学意义(P>0.05),但是不同性别患者的PTEN基因表达差异明显,男性患者PTEN基因的低表达比例明显高于女性患者,(P=0.015)。胃癌组织中PTEN基因表达水平明显低于癌旁组织,胃癌组织中PTEN表达高的患者其预后生存时间明显长于表达低的患者(P=0.0145)。结论 PTEN基因可作为预测手术治疗患者预后的主要生物标志物之一。
Objective To investigate the expression of PTEN gene in gastric cancer and its adjacent tissues and its effect on the prognosis of patients. Methods The clinical data and postoperative survival follow-up data of 113 patients with gastric cancer admitted to our hospital from January 1991 to December 1996 were collected. Tissue microarrays were made from the corresponding cancerous tissues and adjacent tissues. Method to obtain the PTEN gene in which the expression score. To analyze the relationship between PTEN gene expression and clinicopathological parameters and prognosis of patients. Results Of the 113 patients, valid information was obtained in 108 patients. The expression level of PTEN gene in 108 cases of gastric cancer was significantly lower than that in adjacent non-cancerous tissues (P <0.001). There was no significant difference in the expression of PTEN gene and the age of patients, the invasion depth of invasive tumor, lymph node metastasis, distant metastasis rate and TNM stage (P> 0.05), but there was significant difference in PTEN gene expression between male and female patients The low expression of PTEN was significantly higher in women than in women (P = 0.015). The expression of PTEN gene in gastric cancer tissues was significantly lower than that in paracancer tissues. The prognosis of patients with high PTEN expression in gastric cancer tissues was significantly longer than that in patients with low expression (P = 0.0145). Conclusions PTEN gene may be one of the major biomarkers for predicting the prognosis of patients undergoing surgical treatment.