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目的探讨卡前列素氨丁三醇联合卡贝缩宫素对前置胎盘剖宫产产后出血的疗效。方法将2012年9月至2016年9月于北京海军总医院行剖宫产的102例前置胎盘产妇分为两组,每组51例。对照组胎儿娩出后采取传统综合治疗措施作为基础治疗,使用卡贝缩宫素促宫缩;观察组在此基础上再联合使用卡前列素氨丁三醇。对比两组患者的出血/止血情况(术中出血量、术后2 h出血量、止血时间、输血及子宫切除例数)、手术及术后情况(手术时间、住院时间、术后并发症)及临床疗效指标。结果观察组临床疗效、术中出血量、术后2 h出血量、止血时间、手术时间、住院时间等均优于对照组(P<0.05);血液生化指标(白细胞计数、白介素、肿瘤坏死因子)、输血例数、子宫切除例数观察组优于对照组,但差异无统计学意义(P>0.05)。结论卡前列素氨丁三醇联合卡贝缩宫素对前置胎盘剖宫产产后出血具有较为确切的疗效。
Objective To investigate the effect of carboprost trometamol combined with carbetocin on pre-placental cesarean section postpartum hemorrhage. Methods 102 cases of placenta previa from September 2012 to September 2016 in Beijing Navy General Hospital were divided into two groups, 51 cases in each group. The control group of fetuses after delivery of traditional comprehensive treatment as the basis for treatment, the use of carbetocin to promote contractions; observation group on this basis combined with the use of carboprost tromethamine. The bleeding and hemostasis (intraoperative blood loss, blood loss at 2 h after surgery, bleeding time, number of transfusions and hysterectomy), operation and postoperative conditions (operation time, hospital stay, postoperative complications) were compared between the two groups. And clinical efficacy indicators. Results The clinical curative effect, intraoperative blood loss, blood loss at 2 h after operation, bleeding time, operation time and hospital stay were all better than those in the control group (P <0.05). The blood biochemical parameters (leucocyte count, interleukin, tumor necrosis factor ), The number of blood transfusion and the number of cases of hysterectomy in the observation group were superior to those in the control group, but the difference was not statistically significant (P> 0.05). Conclusion The combination of carboprost trometamol and carbetocin has a definite effect on cesarean section postpartum hemorrhage.