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孕期测定雌三醇(E_3)是了解胎儿胎盘单位功能的一项重要手段。为了确定孕妇唾液中E_3和血清中E_3含量是否同样随妊娠周数的增加而增加,作者对正常孕妇最后10周期间的E_3含量变化作了观察,以估计其临床实用价值。既往收集24小时尿测定E_3含量的方法慢且不方便,而取静脉血测定法虽快,但需反复穿刺会增加病人不适。采用唾液测定E_3含量有很多优点:标本容易收集,病人可自送标本;与收集尿标本相比,唾液不受时间和容量的限制。作者测定唾液中E_3总浓度,并与同时测定血清中E_3总浓度和未结合E_3浓度进行比较。
Determination of estriol during pregnancy (E_3) is an important means of understanding the function of fetal placenta. In order to determine whether E3 in serum of pregnant women and E3 in serum are also increased with the increase of gestational weeks, the authors observed the changes of E3 levels in the normal pregnant women during the last 10 weeks to evaluate its clinical practical value. Previous collection of 24-hour urinalysis E_3 content of the method is slow and inconvenient, while the venous blood taken fast, but need repeated puncture will increase patient discomfort. The use of saliva to measure E_3 content has many advantages: the specimen is easy to collect and the patient can send the specimen in self; the saliva is independent of time and volume as compared with the collection of urine specimens. The authors measured the total concentration of E_3 in saliva and compared it with the simultaneous determination of the total E_3 concentration in serum and the unbound E_3 concentration.