作者们采用配对交叉方法比较两种常用血管收缩剂二甲唑啉和可卡因对鼻粘膜血流和鼻气流的影响。12名志愿者参与研究,全部除外鼻中隔偏曲和鼻窦感染。以双盲法选择首先试验的制剂,两种制剂试验之间至少间隔48小时。应用主动前鼻测压法间接评价鼻粘膜血容量和激光多普勒流量测定评价鼻粘膜血流量, The authors used paired crossover methods to compare the effects of two commonly used vasoconstrictors, dicarboxal and cocaine, on nasal mucosal blood flow and nasal airflow. Twelve volunteers participated in the study, except for all nasal septum deviation and sinus infections. The first trial of the formulation was chosen in a double-blind fashion with at least 48 hours between trials of the two formulations. Nasal mucosal blood flow and laser Doppler flow rate were evaluated indirectly by active anterior nasal pressure measurement.