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目的:观察黄芪总苷对兔动脉粥样硬化斑块胶原含量的影响,并对其机制进行初步探讨。方法:高胆固醇饮食12周建立兔动脉粥样硬化(atherosclerosis,AS)病变模型,黄芪总苷10、30、90mg/kg·d灌胃。取主动脉内膜组织分别采用western、免疫组织化学方法检测斑块组织中Ras p21蛋白、SMCα-actin、c-jun、c-fos、c-myc蛋白含量。结果:黄芪总苷能明显降低斑块中SMCα-actin、Ras p21蛋白,c-jun、c-fos、c-myc蛋白和mRNA表达。结论:黄芪总苷能降低动脉粥样硬化斑块中平滑肌含量,其机制可能与降低Ras、c-jun、c-fos、c-myc表达有关。
OBJECTIVE: To observe the effects of total glucosides of astragalus on collagen content in rabbit atherosclerotic plaque, and to discuss its mechanism. METHODS: Atherosclerosis (AS) lesion model was established in high cholesterol diet for 12 weeks. Astragaloside 10, 30, and 90 mg/kg·d were intragastrically administered. The aortic intima tissue was detected by western and immunohistochemical methods to detect Ras p21 protein, SMC α-actin, c-jun, c-fos, c-myc protein content in the plaque tissue. RESULTS: Total glycosides of astragalus could significantly reduce the expression of SMCα-actin, Ras p21 protein, c-jun, c-fos, c-myc protein and mRNA in plaques. CONCLUSION: Astragalosides can reduce the content of smooth muscle in atherosclerotic plaques, and its mechanism may be related to the decrease of expression of Ras, c-jun, c-fos and c-myc.