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目的 :评价泪囊鼻腔吻合术联合应用丝裂霉素C(mitomycinc ,MMC)的临床疗效。方法 :采取随机对照临床试验方法 ,将 36例 ,4 2只眼慢性泪囊炎患者随机分为MMC组和对照组 ,每组 2 1只眼 ,其中 6例为左右眼对照。所有患者年龄在2 0～ 5 6岁之间 ,均为首次手术。两组手术方式相同 ,其中 ,MMC组术中置一含 0 2mg/mlMMC棉片于泪囊鼻腔粘膜吻合口内 ,30分钟后自鼻腔抽出。术后随访 10个月 ,观察并记录溢泪症状改善情况、下睑缘角膜间泪液弧高度 (theheightoftearmeniscus)以及泪道冲洗情况 ,并作统计分析。结果 :MMC组有 2 0只眼 (95 2 % )溢泪症状完全消失 ,1只眼症状无改善 ;对照组有 14只眼 (6 6 7% )症状消失 ,4只眼 (19 0 % )症状好转 ,3只眼 (14 3% )无效。两组差异有显著性 (x2 =6 0 5 84 ,P <0 0 5 ) ;随访期间 ,测量下睑缘角膜间泪液弧高度 ,MMC组正常者 19只眼 (90 5 % ) ,偏高 1只眼 (4 8% ) ,较高 1只眼 (4 8% ) ;而对照组正常者 12只眼 (6 3 2 % ) ,偏高 6只眼 (2 8 6 % ) ,较高 3只眼 (14 3% ) ,两组间有显著性差异 (x2 =6 14 88,P <0 0 5 ) ;随访期间泪道冲洗 ,MMC组 1只眼 (4 8% )阻塞 ,对照组 3只眼 (14 3% )阻塞。所有病例切口均一期愈合 ,7日拆线 ,未发现鼻腔出血、鼻粘膜坏死及?
Objective: To evaluate the clinical efficacy of dacryocystorhinostomy combined with mitomycin C (MMC). Methods: Thirty-six patients (42 eyes) with chronic dacryocystitis were randomly divided into MMC group and control group, with 21 eyes in each group. Six of them were left and right eyes. All patients aged 20 to 56 years old, were the first surgery. The two groups were operated in the same way. Among them, MMC group received a 0.2 mg / ml MMC on the anastomosis of nasal mucosa in the dacryocyst and left the nasal cavity 30 minutes later. The patients were followed up for 10 months. The improvement of overflowing tears, theheightoftearmeniscus and lacrimal duct flushing were observed and recorded, and statistical analysis was made. RESULTS: In OVX group, 20 cases (95.2%) had complete disappearance of overflow tears and no improvement in 1 eye. In control group, 14 eyes (66.7%) disappeared and 4 eyes (190%) disappeared, The symptoms improved, 3 eyes (14 3%) is invalid. There was significant difference between the two groups (χ2 = 6 05 84, P 0 05). During the follow-up period, the interocular tear arc height was measured in 19 eyes (90 5%) of normal group and 1 Eyes (48%) and higher one eye (48%). In the control group, 12 eyes (62.2%) and 6 eyes (286% (14.3%) had significant difference between the two groups (χ2 = 6 14 88, P 0 05). During lacrimal passage during follow-up, one eye (48% Eye (14 3%) blocked. All cases were incision healed, stitches on the 7th, found no nasal bleeding, nasal mucosal necrosis and?